Solid lipid nanoparticle-loaded mucoadhesive buccal films – Critical quality attributes and in vitro safety & efficacy

The objective of this work was to develop and characterize solid lipid nanoparticle (SLN)-loaded mucoadhesive films reveal their potential as successful drug formulations. SLNs based on (Lipoid S100) surfactant (polysorbate 80) were prepared using the solvent-injection method, properties examined experimental designs. Further, marker coumarin 6 (C6) solubilized in particles a model for lipophilic drug. Lipid concentrations influenced particle size, while C6 had minor impact. size distribution narrow storage stability satisfactory 4 months (4 ?). incorporation nanoparticles into film matrix consisting HPMC glycerol, increased thickness flexibility, slightly decreased mechanical strength. mucin interaction disintegration time unimpaired. Film uniformity satisfactory. Solubilisation reduced rate extent permeation through monolayer mucus-producing HT29-MTX cells. When incorporated film, effect compensated for. In conclusion, project first step development an SLN-loaded formulation served its purpose revealing formulation’s uniformity, mucoadhesiveness biocompatibility.